In the field of medical anomalies, Few conditions arouse as much curiosity and concern as aquagenic urticariacommonly known as “water allergy”.
This rare disease turns the seemingly innocuous act of coming into contact with water into a tormenting ordeal for those who suffer from it.
One of these people is Loren Montefusco, 22, from South Carolina, USA. According to health experts Samuel J. White and Philippe B. Wilson in a column for The ConversationMontefusco’s life is marked by the unbearable sensation of a deep itch on his skin at the simple touch of water. A disconcerting affliction that you have to deal with daily.
Why does water allergy occur?
Water allergy is thought to result from an abnormal immune response caused by the interaction of water with the skin. Somehow, water triggers an alarm response in the immune system. This causes the release of substances such as histamine, which causes hives, welts and itching..
The researchers identified mutations in specific genes associated with water allergy, such as the FABP5 gene, which is crucial for the skin’s barrier function. Mutations in this gene alter the skin’s ability to repel water, triggering an inflammatory response.
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Variations in genes involved in immune regulation and skin integrity also contribute to susceptibility. However, Environmental factors such as hormonal changes or exposure to chemicals can influence its severity.
Uncover the secrets of water allergy
Understanding the genetic basis allows us to know how the disease occurs and what therapies are possible. The identification of specific genetic markers allows the development of personalized treatments that target the underlying mechanismsexperts say.
Despite these advances, There is still a lot of ignorance about water allergy. However, By integrating knowledge of genetics, immunology and dermatology, scientists aim to uncover the secrets of this rare water allergyin hopes of improving diagnosis and treatment.
Recent trends suggest a gradual increase in casesdriven by greater awareness among healthcare professionals and improved diagnostic capabilities.
According to current estimates, fewer than 100 cases have been recorded worldwide.
The rarity of water allergy contributes to its mystique. The disease leaves an indelible mark on those affected, shaping their experiences in profound and unexpected ways.. According to current estimates, fewer than 100 cases have been recorded worldwide. This fact underlines its status as one of the rarest forms of urticaria.
Treatments for water allergy
Conventional allergy treatments (antihistamines, corticosteroids) offer temporary reliefbut may not treat the underlying cause.
To the experimental therapiessuch as phototherapy (exposure of the skin to ultraviolet light), aim to calm the immune response and reduce inflammation. This therapy has shown promise in relieving symptoms.
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You biological agentsso-called “large molecule drugs” made from proteins, target specific immune pathways involved in allergic reactions. Offer a more specific therapeutic approach with potential for long-term treatment of symptoms.
Avoiding water is complicated and requires careful planning, including alternative ways to stay clean.
The use of protective barriers, such as emollient creamscan help create a layer between the skin and water, which can help reduce the severity and frequency of symptoms.
Psychological support for the treatment of water allergy
Counseling and support groups provide a safe space for people to overcome emotional difficulties associated with a chronic and misunderstood disease such as aquagenic urticaria.
Offering strategies to cope with illness and build resilience can help patients better deal with the uncertainties and stress factors of your illnessimproving your overall quality of life.
News reference:
https://theconversation.com/water-allergy-a-debilitating-but-thankfully-rare-condition-225107
